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Combined Cyberknife Radiosurgery (SBRT) And Dendritic Cell
Therapy
An Option in Cancer When Standard Treatments Have Failed or Cannot Be Administered
Radiotherapy is one of the cornerstones in the management of cancer for almost 100 years now. Stereotactic Body Radiotherapy (SBRT) is the most advanced form of radiotherapy currently and is indicated for specific situations. It is a sophisticated method involving precise 3 dimensional, high dose radiations to the tumour, with minimum possible radiation to the normal tissue. Cyberknife, is the best available SBRT machine today because of its robotic approach. The technique of SBRT with CyberKnife is also known as Robotic Radiosurgery. It is offered when surgery is indicated but is not possible or when the patient is totally unwilling for the surgery. It is also indicated when the tumour persists or recurs after the conventional therapies.
In cancer management it’s not just the sophisticated treatment that helps. It is the body immunity that kills the remaining few cancer cells with the standard treatment. The routine treatment helps in bringing down the cancer cell burden to a level where body can fight effectively. Hence immunity of body plays a crucial role in getting rid of cancer. Autologous (patient’s own) Dendritic cell therapy is a type of cancer vaccine, which enhances the body’s own immunity against cancer cells. Dendritic cells are normally present but become deficient in cancer. Dendritic cells carry cancer peptides (proteins secreted by the cancer cells) and helps in delivering cancer peptides to the lymph nodes which in turn induces an anticancer T cell response in the body. Following an encounter with either tumour derived peptides or tumour cells in circulation, these sensitized T cells kill the cancer cells. Also, it is very logical to combine the conventional therapies with the methods which improve body immunity. Studies have confirmed the safety and efficacy of Autologous Dendritic cell vaccine and have also demonstrated increase in the median survival of patients.
Combination therapy in cancer treatment has been the best way in handling cancer. Multimodality treatment approach results in a more desirable disease control. High end radiotherapy like Cyberknife results in considerable reduction of tumour burden. Detection and killing of the invisible cancer cells distributed in the body is invariably relied on the body’s immune system. Therefore, combining Cyberknife with Autologous immunotherapy offers an effective approach to combat cancer.
We are offering the combination of Cyberknife radiosurgery and Autologous Dendritic Cell vaccine to cancer patients. During Cyberknife radiosurgery, large numbers of cancer cells are broken down and tumour derived proteins and peptides are released. Administration of patient’s own dendritic cells along with cyberknife radiosurgery might help in improving the control rate. This might be of particular benefit in immunogenic cancers such as renal cell carcinoma and melanoma.
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