Neuroblastoma Cancer Risk Factors and Prevention Measures

Several factors increase the risk of neuroblastoma cancer. However, neuroblastoma occurs spontaneously without any underlying risk factors in many cases. Individuals with genetic abnormalities that increase their risk of neuroblastoma should consult with a genetic counselor to determine the severity of the risk. Currently, effective neuroblastoma prevention measures are not available.

What are Neuroblastoma Risk Factors?

Some of the common neuroblastoma risk factors are:

What are Neuroblastoma Prevention Measures?

Like other childhood cancers, there are currently no established neuroblastoma prevention measures for preventing the occurrence of this condition. However, a healthy lifestyle and consumption of healthy food reduce the risk of neuroblastoma by enhancing the activity of the immune system. It has also been reported that women consuming folic acid or multivitamins during pregnancy have offspring that have a reduced neuroblastoma risk. Further studies are required to establish this neuroblastoma prevention measure. Individuals with a family history of neuroblastoma or having familial neuroblastoma in their families should consult with a genetic counselor to determine the exact risk of developing this condition.


The risk factors for neuroblastoma include age, heredity, genetic predisposition, family history, chromosomal abnormalities, MYCN amplification, and birth defects (congenital anomalies). Presently, there is no one specific neuroblastoma prevention measure that effectively lowers the risk of disease occurrence.

Frequently Asked Questions

Neuroblastoma most commonly affects children and individuals with chromosomal aberrations, the presence of a genetic predisposition to neuroblastoma, people of specific races and ethnicities with MYCN amplification, and individuals exposed to environmental factors.

There is no established neuroblastoma prevention measure. Theoretically, like in other cancers, lifestyle choices may reduce the risk of neuroblastoma. However, it has yet to be validated by the studies.

The recurrence of neuroblastoma depends on several factors, including the location and characteristics of the disease. Studies have found that approximately 50% of the patients with high-risk neuroblastoma who had achieved initial remission have recurrent neuroblastoma.

It is the most aggressive form of neuroblastoma. Patients with high-risk neuroblastoma cancer require aggressive and combinatorial treatment and have a poor prognosis.

Intermediate-risk neuroblastoma is a relatively less aggressive form of neuroblastoma compared with high-risk neuroblastoma cancer but is more aggressive than low-risk neuroblastoma. MYCN may not be amplified in most cases of intermediate-risk neuroblastoma.