×

Kidney Cancer

Overview and Types

What is Kidney Cancer?

Kidney cancer occurs when there is an abnormal growth of cells in the kidney.

The function of the kidneys is to filter the waste from the blood and make urine. The cancer is often diagnosed accidentally through imaging scans.

What is Kidney Tumor?

A kidney tumor is any abnormal growth in or on the kidney. Not all kidney tumors are cancerous. Some are benign growths that don't spread and can often be monitored without treatment.

Difference between Kidney Cancer and Kidney Tumor

"Kidney tumor" is a broader term that includes both cancerous and non-cancerous growths. "Kidney cancer" specifically refers to malignant tumors that can invade surrounding tissue and spread to other organs.

How Common is Kidney Cancer?

Kidney cancer incidence has been rising due to improved imaging that catches tumors earlier and partly due to increasing rates of obesity and hypertension.

First, men are affected roughly twice as often as women.

Second, most cases are diagnosed in people over 50. Most oncologists agree that the rise in incidental detection through ultrasound and CT scans has improved early-stage diagnosis rates.

Whom Does Kidney Cancer Affect?

Kidney cancer affects mainly older adults, especially men above 50. Risk is higher in smokers, obese people, and those with high blood pressure, chronic kidney disease, or family history.

6 Kidney Cancer Types That You Need to Know

  1. Renal Cell Carcinoma
    • Clear Cell Renal Cell Carcinoma (ccRCC)
    • Papillary Renal Cell Carcinoma (PRCC)
    • Chromophobe RCC
    • Collecting Duct RCC
    • Unclassified RCC
    • Clear Cell Papillary RCC
    • Renal Medullary Carcinoma (RMC)
  2. Transitional Cell Cancer
  3. Wilms Tumor
    • Favorable Wilms Tumor
    • Anaplastic Wilms Tumor
  4. Benign Kidney Tumors
    • Angiomyolipoma
    • Oncocytoma
  5. Renal Sarcoma
  6. Metastatic Kidney Cancer

What Are the Stages of Kidney Cancer

Staging maps how far the cancer has spread. It's a bit like grading structural damage before deciding on the repair plan:

  1. Stage 1
  2. Stage 2
  3. Stage 3
  4. Stage 4

Symptoms and Causes

12 Kidney (Renal) Cancer Symptoms & Causes

Kidney cancer symptoms include blood in urine, back pain, fatigue and weight loss, while causes include smoking, obesity, hypertension, genetics and long-term dialysis risk factors.

  1. Blood in the Urine
  2. Pain or Pressure in the Side or Back
  3. A Mass or Lump in the Side or Back
  4. Swelling of the Ankles and Legs
  5. High Blood Pressure
  6. Anemia, which is a Low Red Blood Cell Count
  7. Fatigue
  8. Loss of Appetite
  9. Unexplained Weight Loss
  10. Night Sweats
  11. Swollen Glands in Your Neck
  12. Kidney Failure

Kidney Cancer Causes to Keep an Eye On

Several factors push kidney cells toward cancerous changes.

  1. Smoking
  2. Obesity
  3. High Blood Pressure
  4. Radiation Therapy
  5. Gene Changes (Mutations)
  6. Long-term Dialysis Treatment
  7. Tuberous Sclerosis Complex
  8. Von Hippel-Lindau disease (VHL)
  9. Workplace Exposure to Chlorinated Chemicals
  10. Heredity, which accounts for about 4-6% of Kidney Cancer Cases

When to See a Doctor?

If you notice blood in your urine, persistent back or side pain, or an unexplained lump in the abdomen, it's time to see a specialist.

And if you've got risk factors like chronic kidney disease, obesity, or a family history, regular imaging can catch changes before symptoms appear.

Diagnosis and Treatment

Kidney Tumor Treatment and Diagnosis

Kidney tumor treatment includes surgery, cryoablation, radiofrequency ablation, targeted therapy, immunotherapy, chemotherapy, and radiation. Treatment depends on tumor size, type, and stage, aiming to remove or control cancer effectively.

First, blood tests and urinalysis raise the initial flag.

Second, imaging locates the tumor and checks for spread.

Third, biopsy confirms the diagnosis when needed. Think of it as building a complete picture from multiple angles.

  1. Physical Exam and History
  2. Basic or Complete Metabolic Panel (CMP) to Check Organ Function
  3. Complete Blood Count (CBC) to Check the Blood for Signs of Disease
  4. Urinalysis for Checking Infection, Blood, and Protein in the Urine
  5. Serum Creatinine Levels or Other Kidney Function Tests to Check if the Kidneys are Getting Rid of Waste
  6. Ultrasound to Get Images of Your Kidneys
  7. CT Scan and MRI to Help Diagnose and Stage Kidney Masses
  8. Bone Scan and Chest X-Ray to Find Out if the Cancer Has Spread
  9. Kidney Mass Biopsy to Help Find Out What Type of Tumor You Have

Kidney Cancer - Grading and Staging

  1. Grading
    • Grade 1
    • Grade 2
    • Grade 3
    • Grade 4
  2. Staging
  3. TNM System
  4. Tumor Growth
    • T1 Kidney Cancer
    • T2 Kidney Cancer
    • T3 Kidney Cancer
    • T4 Kidney Cancer
  5. Lymph Node Involvement
    • N0 Kidney Cancer
    • N1 Kidney Cancer
  6. Distant Organ Involvement
    • M0 Kidney Cancer
    • M1 Kidney Cancer
  7. Number System
    • Stage 1
    • Stage 2
    • Stage 3
    • Stage 4

1. Kidney Cancer (Renal Cancer) Treatment

Kidney Cancer (Renal Cancer) Treatment includes surgery, targeted therapy, immunotherapy, chemotherapy, and radiation. Doctors choose treatment based on cancer stage, size, and overall patient health to control or remove cancer.

  • Surgery for Kidney Tumor Treatment
  • Nephrectomy (Remove the Affected Kidney)
  • Partial Nephrectomy (Remove the Tumor From the Kidney)
  • Laparoscopic and Robotic Surgery (Minimally Invasive Surgery)
  • Cytoreductive Nephrectomy
  • Metastasectomy

2. Non-Surgical Treatments

Non-surgical treatments for kidney cancer include cryoablation, radiofrequency ablation, targeted therapy, immunotherapy, chemotherapy, and radiation. These help control or destroy cancer cells without surgery, based on stage and patient condition.

  • Treatment to Freeze Cancer Cells or Cryoablation
  • Treatment to Heat Cancer Cells or Radiofrequency Ablation
  • Treatment for Advanced and Recurrent Kidney Cancer
    1. Surgery to Remove as Much of the Kidney Cancer as Possible
    2. Targeted Therapy
    3. Anti-angiogenesis Therapy
    4. Bevacizumab (Avastin)
    5. Tyrosine Kinase Inhibitors (TKIs)
    6. mTOR Inhibitors
    7. HIF2a Inhibitors
  • Combining Anti-Angiogenesis Inhibitors and Immunotherapy
    1. Immunotherapy
    2. Chemotherapy
    3. Radiation Therapy
    4. Clinical Trials
  • Alternative Medicine
    1. Art Therapy
    2. Exercise
    3. Massage Therapy
    4. Meditation
    5. Music Therapy
    6. Relaxation Exercises
    7. Spirituality

Coping and Support for Kidney Cancer Patients

A kidney cancer diagnosis can be just as challenging as the physical treatment. Almost always, patients benefit from structured support:

  1. Learn Enough About Kidney Cancer to Feel Comfortable Making Treatment Decisions
  2. Taking Care of Yourself
  3. Taking Time for Yourself
  4. Gathering a Support Network
  5. Getting Mental Health Counseling, if Needed

Why Choose HCG for Kidney Cancer Diagnosis and Treatment?

Urologists and oncologists at HCG Cancer Hospital treat kidney cancer from initial imaging through surgery, targeted therapy, and follow-up surveillance.

But even patients with advanced or recurrent kidney cancer get structured multi-modal treatment plans at HCG Cancer Hospital.

Prevention and Risk Factors

Risk Factors of Kidney Cancer

Risk Factors of Kidney Cancer include smoking, obesity, high blood pressure, chronic kidney disease, older age, family history, genetics, long-term dialysis, and exposure to harmful chemicals or previous cancer treatments.

  1. Older Age
  2. Smoking
  3. Obesity
  4. High Blood Pressure (Hypertension)
  5. Treatment for Kidney Failure
  6. Certain Inherited Syndromes
  7. Family History of Kidney Cancer
  8. Overuse of Certain Medications
  9. Chronic Kidney Disease
  10. Long-Term Dialysis
  11. Previous Cancer Treatments

Hereditary Syndromes That Increase the Risk of Kidney Cancer

Hereditary Syndromes That Increase the Risk of Kidney Cancer include Von Hippel-Lindau, Birt-Hogg-Dubé, HLRCC, TSC, and other genetic conditions. These inherited disorders raise the chance of developing kidney cancer.

  1. Von Hippel-Lindau (VHL) Syndrome
  2. Hereditary Papillary Renal Cell Carcinoma (HPRCC)
  3. Birt-Hogg-Dube (BHD) Syndrome
  4. Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC)
  5. Tuberous Sclerosis Complex (TSC) Syndrome
  6. Succinate Dehydrogenase (SDH) Complex Syndrome
  7. BAP1 tumor predisposition syndrome (BAP1 TPS) (HLRCC)

Frequently Asked Questions

It really depends on the type. Renal cell carcinoma can stay slow for years in some people, while other subtypes may behave more aggressively and spread sooner.

Collecting duct carcinoma and sarcomatoid variants are considered the most aggressive, and they often don’t respond as predictably to standard treatments.

When caught early, surgery can eliminate it entirely. Advanced cases shift toward long-term disease management.

When caught early, surgery can eliminate it entirely. Advanced cases shift toward long-term disease management.

Some kidney tumors are benign, and even cancers behave very differently depending on their grade and stage.

Disclaimer: This article is for general informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Please consult a qualified healthcare provider for any questions regarding a medical condition.

Didn't find what you were looking for?

Feel free to reach out to us.

+91
Or reach us directly
Chat With Us
WhatsApp Icon